Chemotherapy is one of the most efficient strategies for cancer therapy, but some cancer cells become insensitive to the appointed chemotherapy drug which is known as drug resistance. Recent years, this issue is the primary cause of chemotherapy failure in clinic, which increased the cancer-related mortality. Natural compounds are biologically active substances present in plants, such as carotenoids, flavonoids, alkaloids, and terpenoids, which have been proposed as possible adjuvants of traditional chemotherapy due to their long-term safety and negligible even inexistent side effects. In this study, we constructed a reduction-sensitive mixed micelles system for targeted delivery of chemotherapy drug doxorubicin and a typical flavnoid component quercetin on tumor to alleviate drug resistance and enhance the antitumor efficiency. This research will provide some useful references for restoring the sensitivity of chemotherapeutic drug to drug resistance tumor.

Dr. Yan Xie obtained her Ph.D. degree in Pharmaceutical Sciences specialization in Traditional Chinese Medicine from SUTCM and Master Degree in Pharmaceutics from China Pharmaceutical University. She is currently a Research Professor in Pharmaceutics of Traditional Chinese Medicine (TCM), member of Research Center for Health and Nutrition in Shanghai University of TCM, committee member of TCM in Pharmaceutical Society of Shanghai, member of the expert database in Shanghai Science and Technology Committee. Dr. Xie’s researches focus on reversal the tumor multidrug resistance by natural active components and the related mechanisms, development of various nano-delivery systems for poorly water-soluble traditional Chinese medicine compounds, and the preclinical studies of TCM new drugs. At present, as a principal investigator, she holds research projects of the National Natural Science Foundation of China, Modernization of Chinese Traditional Medicine Project of Shanghai Science and Technology Commission, Chinese Traditional Nutrition of Shanghai rising interdisciplinary subject of traditional Chinese Medicine, and so on. She published more than 70 peer-reviewed research articles and reviews in the journals of Nano Letter, J Control Release, Nanoscale, Mol Pharm, Acta Pharm Sin B, etc. She is an inventor on 8 patents and obtained 3 new drug Clinical Trial Permission. Dr. Xie has won over 10 awards including the first prize of Pudong Municipal Science and Technological Progress Award, the second prize of Chinese Medical Science and Technology Award of Shanghai, the third prize of Shanghai Municipal Science and Technological Progress Award, Life Science Award of MEIJI Corp, etc. She received several Honorary Titles including Shanghai “Pujiang Program” for Overseas Returnees, Shanghai “Shu Guang” scholar, Shanghai “Rising-Star Program” for Young Scientists.