| Biography | |
|---|---|
 Prof. Ming Chen Zhejiang University, China |
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| Title: Deep Insight into protein-protein interactions of neurodegenerative diseases | |
| Abstract: In systems biology, to reconstruct biological networks is an important step to understand biological systems. Traditionally the network is generated as 2D graph and/or 3D layout. In protein-protein interaction (PPI) network, proteins are notated as nodes and edges represent their interactions/relations. We have developed bioinformatics methods to achieve multiple level 3D models, and even a virtual cell model. Nevertheless, there is less work on the molecular structure visualization inside of the network. Therefore, we were motivated to integrate the protein structures into the PPI network of neurodegenerative diseases, and to complete a database, called NDAtlas; Then, a database extension, named mPPI, was developed to visualize structural interactome in one-to-many manner. In addition, we proposed a sequence-based framework named DeepTrio for PPI prediction using multiscale convolutional neural networks. DeepTrio can be used to evaluate the effect of each protein residue on PPI, which is rendered as an "importance map". | |
| Biography: Prof. Ming Chen received his PhD in Bioinformatics from Bielefeld University, Germany, in 2004. Currently he is working as a full Professor in Bioinformatics at College of Life Sciences, Zhejiang University. His group research work mainly focuses on, computational and functional analysis of transcriptomics, systems biology, and generally bioinformatics education, research and application. Prof. Chen is serving as an academic leader in Bioinformatics at Zhejiang University. He chairs the Bioinformatics society of Zhejiang Province, China. He serves as a committee member of Chinese societies for “Modelling and Simulation of Biological Systems”, “Computational Systems Biology”, “Functional Genomics & Systems Biology”, and “Biomedical Information Technology”. More info is available via his personal webpage: http://bis.zju.edu.cn/binfo/members/ming_chen.htm | |
