Biography
Dr. Xiuquan Zhang
Dr. Xiuquan Zhang
Shunde Hospital of Southern Medical University, China
Title: Reproductive health strategies for genetic abnormalities and birth defects
Abstract: 
Background: 
China is one of the countries with high incidence of birth defects. There are about 1 million birth defects every year, with an average of one birth defect every 30 seconds. Among them, about 20% - 30% of children with early diagnosis and treatment can obtain a better quality of life, 30% - 40% of children died after birth, about 40% will become a lifelong disability. This means that about 400000 families will be involved in the vortex of lifelong pain every year. According to the results of birth defect monitoring and survey of disabled children in China, there are nearly 30 million families that have ever given birth to birth defects, accounting for nearly 1 / 10 of the total number of families in China. In China, the annual cost of treatment for children with birth defects is as high as tens of billions of yuan. In addition, the cost of maintaining the most basic living is as high as tens of billions of yuan, and the indirect cost to the country is about hundreds of billions of yuan yearly.
New Technologies:
With the mutual penetration of reproductive technology, cell engineering, genetic engineering, developmental genetics and medical big data, reproductive genetics, as a new discipline, has created a new branch of genetics. Reproductive genetics is closely related to reproductive health. Reproductive genetic abnormalities can lead to many health problems, such as reproductive disorders, congenital genetic diseases and congenital metabolic diseases.
We cannot ignore the influence of internal and external environment on gametes and embryos, with genetic diseases continue to pass pathogenic genetic factors to their offspring. This requires us to pay close attention to the development of reproductive genetics, and pay more attention to the influence of various factors on gametes, embryos and fetuses. We need to develop and apply the most advanced biotechnology in discovering, diagnosing and intervention to the existing reproductive genetic problems, and ensure the reproductive health.
In the aspect of diagnosis, the extraction of fetal DNA, RNA and fetal cells from maternal blood can be used for non-invasive screening of fetal gene diagnosis. Fluorescence quantitative in situ hybridization, real-time quantitative polymerase chain reaction, primer in situ labeling, spectral karyotype analysis technology, comparative genomic hybridization and gene chip have been used for precise gene diagnosis of embryo and fetus.
In addition, preimplantation genetic diagnosis, prenatal diagnosis and other technologies have carried out a series of tests on the development of embryos and fetuses at various stages of reproductive diagnosis. If these new technologies can be applied to the genetic diagnosis of reproduction and fertility scientifically, they will play an important role in preventing the occurrence of genetic diseases and the birth of congenital birth defects, so as to greatly improve the overall quality of newborns and the overall quality of the population.
Purpose:
From the perspective of genetic factors such as gene variation, chromosome abnormality and congenital dysplasia, we will expound their influence on reproductive health and population quality. Combined with the progress of modern diagnosis and treatment advanced technology, we will summarize the practical value of these technologies in reproductive genetics, and promotes the clinical application of these technologies.
In order to effectively block the occurrence, development and harm of reproductive genetic problems, we will promote the application of reproductive genetic related intervention technology services, and move forward the prevention and control focus of reproductive genetic related problems.
The effective intervention of reproductive genetics is an important measure to improve the health quality of the whole population. In reproductive stage, it is necessary to block the inheritance of congenital diseases, improve the quality of the population. Starting from the level of molecular biology, cytogenetics, embryo and fetal imaging diagnosis and intervention in reproductive stages, and relying on the promotion of new knowledge and new technology, the application of advanced pre-implantation diagnosis, non-invasive early fetal diagnosis, gene chip diagnosis, gene sequencing and other new technologies to the early stage of reproductive genetics can improve the diagnosis and treatment level of reproductive and reproductive health.
Biography: 
Dr. Zhang received his Bachelor’s and Master’s Degree from Central South University Xiangya School of Medicine, and his M.D. and Ph.D. Degree from Shanghai Jiaotong University School of Medicine. He completed his Post-doctorate training in Reproductive Genetics at University of Utah and received his Outstanding Professor in USA. Dr. Zhang experienced working in the field of Obstetrics and Gynecology for over 35 years at Xiangya Second Hospital, Sun Yat-sen University Third Affiliated Hospital, University of Utah Medical Center and Shunde Hospital of Southern Medical University. His research interest involves reproductive genetics, perinatal medicine, and prenatal and preimplantation diagnosis. Now, Dr. Zhang serves as the Chair of Department of Obstetrics and Gynecology, Director of Research Laboratory of Reproductive Genetics at Shunde Hospital of Southern Medical University in Guangdong, China. He serves as several specialty committee members in Society of Guangdong Chinese Medicine and member of Society of American Medicine. Dr. Zhang also serves as Executive Editorial member of Advancement in Genetic Engineering, Editorial board member of World Journal of Obstetrics and Gynecology, and several other international journals.